Department of Veterinary Pathobiology

Aaron Ericsson
Assistant Research Professor

  • DVM, University of Missouri
  • Residency (Laboratory Animal Medicine), MU Comparative Medicine Program
  • PhD (Area Pathobiology), University of Missouri
  • Director, MU Metagenomics Center (http://mumc.missouri.edu/)
  • Co-I, MU Mutant Mouse Resource and Research Center (http://mu-mmrrc.com/)
  • Co-I, Rat Resource and Research Center (http://www.rrrc.us/)

Building Address: S123B Discovery Ridge Building
Phone Number: 573-882-1019
Email: ericssona@missouri.edu

Research Emphasis: gut microbiota, exoelectrogenic bacteria, metagenomics, mucosal immunology, pathology, comparative medicine, translational medicine

Our lab is interested in differences in the composition of the gut microbiota in inbred strains and outbred stocks of mice and rats, factors that drive those differences, and the impact of the resulting enterotypes on rodent models of disease, particularly models of colitis and colitis-associated colorectal cancer.  Using rederivation via embryo transfer and fecal microbiota transfer, we modulate the gut microbiota at birth or later in life respectively, to investigate windows of vulnerability for modulation of the gut microbiota.  Next-generation sequencing platforms are used to characterize the gut microbiota.  Past and ongoing projects have focused on the IL-10 knockout mouse model of inflammatory bowel disease, the Pirc (Apc mutant) rat model of colorectal cancer (CRC), and the Smad3 knockout mouse model of colitis-associated CRC.

We’re also interested in the mechanisms through which certain microbes, such as segmented filamentous bacteria (SFB; see image below), affect the ontogeny of the host immune system.  Specifically, certain mucosa-adherent microbes such as SFB (called exoelectrogens) are thought to induce production of electrical currents at the epithelium capable of recruiting electrotactic gut lymphocytes.  Ongoing studies in our lab investigate the influence of exoelectrogenic bacteria on development of gut-associated lymphoid tissue during early life, and subsequent susceptibility to immune-mediated diseases and conditions.

a Lastly, we collaborate heavily with clinical veterinarians to characterize the gut, respiratory, and dermal microbiota of dogs, cats, horses, cattle, and myriad other species, and examine associations between characteristics of the microbiota that differ between healthy or unaffected individuals and those affected with various conditions.

 

 

 

 

 

 

 

Selected Publications:

Moore, S.G., Ericsson, A.C., Poock, S.E., Melendez, P., and M.C. Lucy. (2017) Hot topic: Metagenomic analysis reveals the microbiome of the virgin and pregnant bovine uterus. Journal of Dairy Science (in press)

Vientós-Plotts, A.I., Ericsson, A.C., Rindt, H., Grobman, M.E., Graham, A., Bishop, K., Cohn, L., and C.R. Reinero. (2017) Dynamic changes of the healthy feline airway microbiota. PLoS One, 12(3): e0173818.
Ericsson, A.C. and C.L. Franklin. (2017) Microbiota and reproducibility of rodent models. Lab Animal (in press)

Ericsson, A.C., Personett, A.R., Turner, G., Dorfmeyer, R.A., and C.L. Franklin. (2017) Variability of Reciprocal Fecal Microbiota Transfer between Mice with Low and High Richness Microbiota. Frontiers in Microbiology (in press)

Ericsson, A.C., Johnson, P.J., Lopes, M., Perry, S., and H. Lanter. (2016) A microbiological map of the healthy equine gastrointestinal tract. PLoS One, 11(11): e0166523. 

Davis, D.J., Doerr, H.M., Grzelak, A.K., Busi, S.B., Jasarevic, E., Ericsson, A.C., and E.C. Bryda. (2016) Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish. Scientific Reports, 6:33726.

Hays, M.P., Ericsson, A.C., Yang, Y., and P.R. Hardwidge. (2016) Vaccinating with conserved E. coli antigens does not alter the mouse intestinal microbiome. BMC Research Notes, 9:401-407.

Davis, D.J., Bryda, E.C., Gillespie, C.H., and A.C. Ericsson. (2016) Microbiota modulates behavior and stress responses in zebrafish larvae. Behavioural Brain Research, 311:219-227. 

Davis, D.J., Bryda, E.C., Gillespie, C.H., and A.C. Ericsson. (2016) Microbiota variation between conventionalized and conventionally-raised zebrafish larvae. Data in Brief, 8:938-943.

Ericsson, A.C., Personett, A.R., Grobman, M.E., Rindt, H., and C.R. Reinero. (2016) Composition and predicted metabolic capacity of upper and lower airway microbiota of healthy dogs in relation to the fecal microbiota.  PLoS One, 11(5): e0154646. 

Burton, E., Ericsson, A.C., O’Connor, E.K., and C.L. Franklin. (2016) Evaluation of fecal microbiota as an adjunct treatment for diarrhea in post-weaning research colony puppies.  Journal of the American Association for Laboratory Animal Science, 55(5):582-587.

Miller, P.G., Bonn, M.B., Franklin, C.L., Ericsson, A.C., and S.C. McKarns. (2015) TNFR2 Deficiency Acts in Concert with Gut Microbiota to Precipitate Sex-biased Spontaneous CNS Demyelinating Autoimmune Disease.  Journal of Immunology, 195(10): 4668-4684.

Hart, M.L., Meyer, A., Johnson, P.J., and A.C. Ericsson. (2015) Comparative Evaluation of DNA Extraction Methods from Feces of Multiple Host Species for Downstream Next-Generation Sequencing.  PLoS One, 10(11): e0143334.

Amos-Landgraf, J., Busi, S., Ericsson, A., McCoy, M., Parker, T., Schehr, R., Hankins, M., Franklin, C., and E.C. Bryda. (2015) Abstract 2880: Modulating disease susceptibility in a model of human colon cancer by microbiome rederivation. Cancer Research 75 (15 suppl): abstract 2880.

Ericsson, A.C., Akter, S., Hanson, M., Busi, S.B., Parker, T., Schehr, R., Hankins, M., Ahner, C.E., Davis, J.W., Franklin, C.L., Amos-Landgraf, J., and E.C. Bryda. (2015) Differential susceptibility to colorectal cancer due to naturally occurring gut microbiota. Oncotarget, 6(32): 33689-33704.

Ericsson, A.C., Turner, G., Montoya, L., Wolfe, A., Meeker, S., Hsu, C., Maggio-Price, L., and C.L. Franklin. (2015)  Isolation of segmented filamentous bacteria from a complex gut microbiota.  BioTechniques, 59(2): 94-98.

Ericsson, A.C., Davis, D.J., Franklin, C.L., and C.E. Hagan. (2015) Exoelectrogenic capacity of host microbiota predicts lymphocyte recruitment to the gut.  Physiological Genomics, 47(7): 243-252.

Ericsson, A.C., and C.L. Franklin.  (2015) Manipulating the gut microbiota: methods and challenges.  ILAR Journal, 56(2): 205-217. (invited review)

Ericsson, A.C., Davis, J.W., Spollen, W., Bivens, N., Givan, S., Hagan, C.E., McIntosh, M., and C.L. Franklin.  (2015)  Effects of vendor and genetic background on the composition of the gut microbiota of inbred mice.  PLoS ONE, 10(2): e0116704.

Sands, S.A., Tsau, S., Yankee, T.M., Parker, B.L., Ericsson, A.C., and S.M. Levine. (2014) The effect of omeprazole on the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice.  BMC Research Notes, 7(1): 605-615. 

Ericsson, A.C., Hagan, C., Davis, D.J., and C. L. Franklin. (2014) A review of segmented filamentous bacteria – commensal microbes with potential effects on research. Comparative Medicine, 64(2): 90-98. 

Ericsson, A.C., Crim, M., and C.L. Franklin. (2013) A brief history of animal modeling.  Missouri Medicine. 110(3): 201-205. 

Lee, K., Kwon, D-N., Ericsson, A., Brown, A.N., Samuel, M., Park, K-W., Walters, E., Kim, J-H., Franklin, C., Murphy, C.N., Prather, R.S., and J-H. Kim. (2013) Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.  Proceedings of the National Academy of Sciences, 111(20): 7260-7265. 

Ortega-Cava, C.F., Raja, S.M., Laiq, Z., Bailey, T.A., Luan, H., Mohapatra, B., Williams, S.H., Ericsson, A.C., Goswami, R., Dimri, M., Duan, L., Band, V., Naramura, M., and H. Band. (2011) Continuous requirement of ErbB2 kinase activity for loss of cell polarity and lumen formation in a novel ErbB2/Neu-driven murine cell line model of metastatic breast cancer.  Journal of Carcinogenesis, 10(29). 

Ghosh, S., Koblinski, J., Johnson, J., Liu, Y., Frazier, S., Ericsson, A., Shi, Z., Crawford, S., and M.S. Stack. (2010) Urinary-type plasminogen activator receptor (uPAR/R)/alpha3beta1 integrin signaling and oral tumor progression. Molecular Cancer Research, 8(2):145-158.   

Ericsson, A., Myles, M., Davis, J.W., Ma, L., Lewis, M., Maggio-Price, L., and C. Franklin. (2010) Noninvasive detection of inflammation-associated colon cancer in a mouse model. Neoplasia, 12(12): 1054-1065. 

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