Department of Veterinary Pathobiology

Alpana Ray
Research Professor

  • MS, University of Calcutta
  • PhD, University of Calcutta

Building Address: 126 Connaway Hall
Phone Number: 573-882-6728
Email: RayAL@missouri.edu

Research Emphasis: : Inflammation is an organism’s protective mechanism to cope with the altered cellular environment, trauma, injury and/or infection. While acute inflammation (which is resolved quickly) has many beneficial effects, chronic inflammation is a serious problem and leads to many pathophysiological conditions. Major focus of my research has been the elucidation of the molecular events associated with amyloidosis, arthritis, atherosclerosis and cancer, all of which are results of abnormal gene expression during persistent and chronic inflammation.  My current research involve studies on the proliferation, metastasis and recurrence of breast cancer.  I have been focusing on several regulatory factors that are crucial in angiogenesis and particularly in the angiogenic switch.  Since tumor dormancy involves angiogenic suppression and cancer recurrence is triggered by angiogenic switch with re-initiation of angiogenesis, my research focuses on these two events.  In another project, I am investigating the contribution of complex epigenetic processes involving various transcriptional regulators and DNA conformation, such as Z-DNA structure, in the regulation of genes including several proteases that are associated with metastasis.  Also, I am working on the role of oncogene Ras in regulating angiogenesis in breast cancer. My goal is to develop new therapeutic measure against tumor angiogenesis to control tumor cell dormancy and prevent cancer recurrence and metastasis.

Selected Publications:

  • Alalem, M., Ray, A. and Ray, B. K. (2016) Metformin induces degradation of mTOR protein in breast cancer cells.  Cancer Med. 2016 Nov;5(11):3194-3204. doi: 10.1002/cam4.896. Epub 2016 Oct 17
  • Alalem, M, Ray, A. and Ray, B. K. (2016) Metformin treatment decreases mTOR mRNA level in MCF7 breast cancer cells. Ibnosina J. Med. Biomed Sci 99-108. journals.sfu.ca/ijmbs/index.php/ijmbs/article/viewFile/620/1183
  • Ray, A. and Ray, B. K. (2015) Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer.  Cancer Med. 2015 Feb;4(2):224-34. doi: 10.1002/cam4.362. Epub 2014 Nov 30
  • Ray, A., Alalem, M., and Ray, B. K. (2013) Loss of epigenetic Kruppel-like factor 4-histone deacetylase –mediated transcriptional suppression is crucial in increasing vascular endothelial growth factor expression in breast cancer.  J Biol Chem. 2013 Sep 20; 288(38): 27232–27242.
    Published online 2013 Aug 6. doi:  10.1074/jbc.M113.481184
  • Ray, B.K., Dhar, S., Henry, C., Rich, A. and Ray, A. (2013) Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer:  crosstalk between MeCP2 and NF1 transcription factor family. Cancer Res. 2013 Jan 15;73(2):736-44. doi: 10.1158/0008-5472.CAN-12-2601. Epub 2012 Nov 7.
  • Ray, B.K., Dhar, S., Shakya, A. and Ray, A. (2011) Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):103-8. doi: 10.1073/pnas.1008831108. Epub 2010 Dec 20.
  • Ray, A., Dhar, S., and Ray, B. K. (2011) Control of VEGF expression in triple negative breast carcinoma cells by suppression of SAF-1 transcription factor activity.  Mol Cancer Res. 2011 Aug;9(8):1030-41. doi: 10.1158/1541-7786.MCR-10-0598. Epub 2011 Jun 10
  • Ray, B.K., Dhar, S., and Ray, A. (2010) TGF-1 mediated activation of NF-B contributes to enhanced ADAM-12 expression in mammary carcinoma cells. Mol Cancer Res. 2010 Sep;8(9):1261-70. doi: 10.1158/1541-7786.MCR-10-0212. Epub 2010 Aug 5
  • Mukhopadhyay, S., Mukherjee, S., Ray, B.K., Ray, A., Stone, W.L., and Das, S.K. (2010) Antioxidant liposomes protect against CEES-Induced Lung Injury by decreasing SAF-1/MAZ-mediated inflammation in the guinea pig lung. J Biochem Mol Toxicol. 2010 May-Jun;24(3):187-94. doi: 10.1002/jbt.20329.
  • Kumar, D., Ray, A., and Ray, B.K. (2009) Transcriptional synergy mediated by SAF-1 and AP-1: critical role   of N-terminal polyalanine and two zinc finger domains of SAF-1.  J Biol Chem. 2009 Jan 16;284(3):1853-62. doi: 10.1074/jbc.M806289200. Epub 2008 Nov 21.
  • Ray, A., Dhar, S., Shakya, A., Ray, P., Okada, Y. and Ray, B.K. (2009) SAF-3, a novel variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation.  FEBS J. 2009 Aug;276(15):4276-86. doi: 10.1111/j.1742-4658.2009.07136.x. Epub 2009 Jul 3.
  • Ray, A. and Ray, B.K. (2008) An inflammation-responsive transcription factor in the pathophysiology of osteoarthritis. Biorheology. 2008;45(3-4):399-409.
  • Kovacevic, A., Hammer, A., Stadelmeyer, E., Windischhofer, W., Sundl, M., Ray, A., Schweighofer, N., Friedl, G., Windhager, R., Sattler, W., and malle, E. (2008) Expression of Serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells aand human osteosarcome cell lines. J Cell Biochem. 2008 Feb 15; 103(3): 994–1004. doi:  10.1002/jcb.21472
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