Yuksel Agca
Associate Professor
DVM, MS, PhD
- D.V.M., Ankara University, Turkey
- M.S., University of Wisconsin-Madison
- Ph.D., Purdue University-West Lafayette
- Post-doctoral fellow, Indiana University School of Medicine
- Co-I, Mutant Mouse Resource and Research Center (MMRRC)
- Co-I, Rat Resource and Research Center (RRRC)
Building Address: S122 Discovery Drive
Phone Number: 884 0311
Email: agcay@missouri.edu
Research Emphasis: There are challenges for making dramatic research advances in the areas of biomedical research. Thus, it is imperative to have optimal animal models to investigate cellular, molecular and structural basis of human disorders and to apply this enhanced understanding to the development of a new generation of reproductive other therapeutic approaches. We have engaged in the studies involving several diverse research areas including reproductive biology, transgenic rodent model, molecular reproduction, neurodegenerations, and bone pathology with a team of collaborators. We value basic research and it’s translation into practical applications in the biomedical fields. In addition, Interactions involving cross-disciplinary knowledge and technology is crucial for the development and public acceptance of new tools and methodologies that will ultimately serve the reproductive well-being of both humans and animals as well as human general medicine. Our research includes cellular, biophysical, and molecular aspects of cryobiology and biology of mammalian germplasm. We perform basic research and subsequently translate the gained knowledge toward development of reproductive technologies as they relate to gamete, embryo, and gonadal tissue biotechnologies including genome cryobanking, human diseases model development, and gene transfer. We are also interested in genome resource cryobanking of scientifically important mutant rodent models for human diseases. One of the research interests that we currently pursuing is the use of laboratory rats as models to develop reproductive therapy strategies for women via ovarian tissue cryopreservation and subsequent auto-transplantation for the prevention of infertility and bone loss. In addition, our ongoing research effort is directed to investigate diet and menopause induced cognitive, brain molecular, cellular and pathologic changes using transgenic rat models of Alzheimer’s disease that we developed in our laboratory.
Teaching Responsibilities: Laboratory rodents reproduction
Selected Publications since 2011 (Google Scholar Citations):
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Wuri L, Agca C, Agca Y (2019). Euthanasia via CO2 inhalation causes premature cortical granule exocytosis in mouse oocytes and influences in-vitro fertilization and embryo development. Mol. Reprod. Dev. doi: 10.1002/mrd.23167.
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Agca Y (2019). In vitro culture of rat pre-implantation embryos. Methods in Molecular Biology, Springer Nature. In Embryo Culture 2006:33-43. doi: 10.1007/978-1-4939-9566-0_3.
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Kim S, Hooper S, Agca C, Agca Y (2016). Post-thaw ATP supplementation enhances cryoprotective effect of iodixanol in rat spermatozoa. Reproductive Biology & Endocrinology. DOI: 10.1186/s12958-016-0141-5.
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Agca C and Agca Y (2014). Molecular and ultrastuctural changes of rat pre-implantation embryos during two-cell developmental arrest. J Assisted Reproduction and Genetics DOI: 10.1007/s10815-014-0213-4.
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Varisli O, Agca C, Agca Y (2013). Short-term storage of rat sperm in the presence of various extenders . J. American Association for Laboratory Animal Sci. 2:732-737.
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Agca C, Yakan A, Agca Y (2013). Estrus synchronization and ovarian hyper-stimulation treatments have negligible effects on cumulus oocyte complex gene expression whereas induction of ovulation causes major expression changes. Mol Reprod Dev. 80:102-117.
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Kim S, Agca C, Agca Y. (2013). Effects of various physical stress factors on mitochondrial function and reactive oxygen species in rat spermatozoa. Reproduction, Fertility and Development, 25:1051-1064.
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Kim S, Agca C, Agca Y. (2012). Changes in rat spermatozoa function after cooling, cryopreservation and centrifugation processes. Cryobiology, 65:215-223.
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Agca Y. (2012). Genome resource banking of biomedically important laboratory animals. Theriogenology78:1653-1665.
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Aksu DA, Agca C, Aksu S, Bagis H, Akkoc T, Caputcu AT, Arat S, Taskin AC, Kizil SH, Karasahin T, Akyol N, Satilmis M, Sagirkaya H, Ustuner B, Nur Z, Agca Y. (2012). Gene expression profiles of vitrified in vitro- and in vivo-derived bovine blastocysts. Molecular Reproduction and Development, 79:613-625.
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Seye C, Agca Y, Agca C, Derbigny W (2012). P2Y2 Receptor-mediated Lymphotoxin-α (LTA) Secretion Regulates Intercellular Cell Adhesion Molecule (ICAM)-1 Expression in Vascular Smooth Muscle Cells. Journal of Biological Chemistry 23:10535-10543.
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